San Jose Convention Center
 San Jose, CA USA

 

UV light blocks EGFR signaling in human cancer cell lines (Paper Presentation)

Paper 6854-20 of Conference 6854

Authors(s): Maria Teresa C. A.Neves-Petersen, Soren Klitgaard, Meg Duroux, Steffen B. Petersen, Aalborg Univ. (Denmark)

 

Date: Tuesday, 22 January 2008
 
A combination of bioinformatics, biophysical, advanced laser studies and cell biology lead to the realization that laser-pulsed UV light stops cancer growth and induces apoptosis. We show that laser-pulsed UV illumination of two different skin-derived cancer cell lines, Cal-39 and A431, both overexpressing the EGF receptor, leads to arrest of the EGFR signaling pathway. Since the EGF receptor is often overexpressed in cancers and other proliferative skin disorders, it might be possible to significantly reduce the proliferative potential of these cells making them good targets for laser-pulsed UV-light treatment.
 

 Photonic molecular immobilization technology and its use for nanolabeling, ultra-sensitive microarray sensing, and new biomarkers discovery (Paper Presentation)

 

Paper 6848-24 of Conference 6848

 

Authors(s): Maria Teresa C. A.Neves-Petersen, Meg Duroux, Esben Skovsen, Laurent Duroux, Steffen B. Petersen, Aalborg Univ. (Denmark)

 

Date: Monday, 21 January 2008
 
Photonic induced immobilisation is a novel technology that results in spatially oriented and localised covalent coupling of biomolecules onto surfaces. Arrays of bio-molecules have been created with a high degree of reproducibility, with individual spot size defined by the area of the focal spot of light on the sensor surface. Biosensing with this technology has been successfully implemented in order to create arrays of immunoglobulins. Complex protein patterns can be written using bitmaps at high resolution onto substrates. We demonstrate A new microarray sensing technology and photonics based watermarking with nanotechnology and therapeutical applications (bioactive carrier nanoparticles).
 

 
 
 
 
New Frontiers in Micro and Nano Photonics
23 - 26 April 2008, Florence (Italy)
 Link here
Selected papers will be published in an issue of the Journal of Biophotonics